Concepedia

Validation of bovine hoof slices as a model for infected human toenails: in vitro ciclopirox transungual permeation

Daniela Monti, L Saccomani, Patrizia Chetoni, S. Burgalassi, Silvia Tampucci, F. Mailland

British Journal of Dermatology · 2011 · 66 citations · 20 references

DOI

Abstract

This study confirms the validity of bovine hoof slices as a model for infected human nails, and suggests a substantial equivalence between the two models. Following P-3051 application, CPX reaches fungicidal concentrations in and through human infected toenails.

References

20

Skin Permeability In Vivo: Comparison in Rat, Rabbit, Pig and Man

M.J. Bartek, John A. Labudde, Howard I. Maïbach · Journal of Investigative Dermatology · 1972 · 502 citations · Full text

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The Use of Reconstructed Human Epidermis for Skin Absorption Testing: Results of the Validation Study

Monika Schäfer‐Korting, Udo Bock, W. Diembeck et al. · Alternatives to Laboratory Animals · 2008 · 225 citations

In-vitro Permeability of the Human Nail and of a Keratin Membrane from Bovine Hooves: Prediction of the Penetration Rate of Antimycotics through the Nail Plate and their Efficacy

Dirk Mertin, B. Lippold · Journal of Pharmacy and Pharmacology · 1997 · 126 citations · Full text

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In-vitro Permeability of the Human Nail and of a Keratin Membrane from Bovine Hooves: Influence of the Partition Coefficient Octanol/Water and the Water Solubility of Drugs on their Permeability and Maximum Flux

Dirk Mertin, B. Lippold · Journal of Pharmacy and Pharmacology · 1997 · 105 citations · Full text

, , +16

In vitro permeation of several drugs through the human nail plate: relationship between physicochemical properties and nail permeability of drugs

Yoichi Kobayashi, Tsunehisa Komatsu, Machiko Sumi et al. · European Journal of Pharmaceutical Sciences · 2004 · 102 citations

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