The Journal of Immunology · 1982 · 106 citations · 0 references
Life SciencesCell BiologyImmunologyCell SignalingCellular ImmunologyImmunoregulationCell-mediated ImmunityCytokine BiologyCytokine RegulationImmune RegulationImmune ResponseInterferon ResponsesImmune Cell Cytokine ProductionInhibition Of Interferon ResponsesInterferon Gamma ProductionInterferon Gamma ResponseInterferon ProductionInterferon-gamma ResponsesSuppressor Cell BiologyT Helper Cells
A Lyt-2+ lymphocyte is responsible for immune interferon (IFN gamma) production in mitogen-stimulated mouse spleen cell cultures. A Lyt-1+ helper cell is required for the induction of IFN gamma. Interleukin 2 (IL 2) can specifically replace the Lyt 1 cell requirement. IL 2 will also abrogate suppressor cell inhibition of IFN gamma production. IFN gamma production appears to be regulated by a dynamic interaction between helper cells (source of IL 2), suppressor cells (absorption of IL 2?) and IFN gammna-producer cells.