Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Rosalind C. Lee, Rhonda Feinbaum, Victor Ambros · Cell · 1993 · 12.8K citations · Full text

Life Sciences, Genetics, Molecular Genetics +7

Alternative isoform regulation in human tissue transcriptomes

Eric T. Wang, Rickard Sandberg, Shujun Luo et al. · Nature · 2008 · 5.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Frequent deletions and down-regulation of micro- RNA genes <i>miR15</i> and <i>miR16</i> at 13q14 in chronic lymphocytic leukemia

George A. Calin, Calin Dan Dumitru, Masayoshi Shimizu et al. · Proceedings of the National Academy of Sciences · 2002 · 5K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +17

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

Bruce Wightman, Ilho Ha, Gary Ruvkun · Cell · 1993 · 4.2K citations · Full text

Life Sciences, Genetics, Molecular Genetics +11

MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing

Andrew Grimson, Kyle Kai‐How Farh, Wendy K. Johnston et al. · Molecular Cell · 2007 · 3.8K citations · Full text

Life Sciences, Genetics, Molecular Biology +10