Concepedia

Quantitative Prediction of In Vivo Drug-Drug Interactions from In Vitro Data Based on Physiological Pharmacokinetics: Use of Maximum Unbound Concentration of Inhibitor at the Inlet to the Liver

Shin-ichi Kanamitsu, Kiyomi Ito, Yuichi Sugiyama

Pharmaceutical Research · 2000 · 133 citations · 14 references

DOI

Concepts

References

14

Methotrexate Pharmacokinetics

Kenneth B. Bischoff, Robert L. Dedrick, Daniel S. Zaharko et al. · Journal of Pharmaceutical Sciences · 1971 · 479 citations · Full text

Animal scale-up

Robert L. Dedrick · Journal of Pharmacokinetics and Biopharmaceutics · 1973 · 394 citations

Tolbutamide hydroxylation by human liver microsomes

John O. Miners, Kerry J. Smith, Richard A. Robson et al. · Biochemical Pharmacology · 1988 · 200 citations

, , +13

SULPHAPHENAZOLE-INDUCED HYPOGLYCÆMIC ATTACKS IN TOLBUTAMIDE-TREATED DIABETICS

L. Korsgaard Christensen, J. Mølholm Hansen, M. Kristensen · The Lancet · 1963 · 197 citations

, , +7

The Metabolic Fate of Tolbutamide in Man and in the Rat

Richard C. Thomas, George J. Ikeda · Journal of Medicinal Chemistry · 1966 · 134 citations

, , +6