Tissue-selective inhibition of prostaglandin synthesis in rat by tepoxalin: Anti-inflammatory without gastropathy?

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Life Sciences, Medicinal Chemistry, Pharmacology +10

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

Wei Xie, Jeffrey G. Chipman, Donald Robertson et al. · Proceedings of the National Academy of Sciences · 1991 · 1.7K citations

Life Sciences, Biochemistry, Molecular Biology +16

Cytoprotection by prostaglandins

André Robert · Gastroenterology · 1979 · 1.1K citations

Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol)

R J Flower, John R. Vane · Nature · 1972 · 779 citations

Medicine, Neuroscience, Pharmacology +9

PREVENTION OF NSAID-INDUCED GASTRIC ULCER WITH MISOPROSTOL: MULTICENTRE, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

D.Y. Graham, NaurangM Agrawal, S H Roth · The Lancet · 1988 · 600 citations

Medicine, Pharmacology, Pharmacotherapy +14