Applied Microbiology · 1961 · 45 citations · 5 references
EngineeringBiotechnologyChemical EngineeringBioprocess EngineeringFermentation EngineeringMicrobial BiotechnologyAntibiotic FermentationAntibiotic ProductionContinuous FermentationMicrobial FermentationReactor DesignReactor ModelingContinuous FlowContinuous Reactor DesignFermentation ModelingFermentation Process DesignFermentation Process EngineeringFermentation YieldsMicrobial Reactor DesignProduction Stages
A graphic method of predicting antibiotic yields in continuous flow reactors is presented and discussed using the novobiocin fermentation as a model process. Extension to other antibiotic fermentations and steroid bioconversions is emphasized. In the case of the novobiocin fermentation it was concluded that a combination of one growth stage and one or two antibiotic production stages would be the most economic reactor system to conduct such a fermentation on a continuous basis.
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