Institutional Repository of the Ruđer Bošković Institute (Ruđer Bošković Institute) · 2003 · 584 citations · 0 references
Open access
PharmacyBiochemistryMedicinal ChemistryBioisosterismFood ChemistryStructure-activity RelationshipsAntioxidant DefenseFood AntioxidantsStructure-activity Relationship AnalysisAntioxidant PropertiesFree Phenolic CompoundsFree Radical ScavengingRadical ScavengersSubstitution Pattern Analysis
The relationship between the structural characteristics of 29 flavonoids and their antiradical activity was studied. The obtained results suggest that the free radical scavenger potential of these polyphenolic compounds closely depends on the particular substitution pattern of free hydroxyl groups on the flavonoid skeleton. The possible mechanism of action of flavonoids lacking B ring OHs as free radical scavengers has been proposed.