THROMBOCYTOPENIA AND ABNORMAL BLEEDING IN MULTIPLE MYELOMA

Abstract

Article1 December 1953THROMBOCYTOPENIA AND ABNORMAL BLEEDING IN MULTIPLE MYELOMATHOMAS N. JAMES, M.D., RAYMOND W. MONTO, M.D., F.A.C.P., JOHN W. REBUCK, M.D.THOMAS N. JAMES, M.D.Search for more papers by this author, RAYMOND W. MONTO, M.D., F.A.C.P.Search for more papers by this author, JOHN W. REBUCK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-6-1281 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the course of multiple myeloma most patients exhibit a tendency to bleed. Although it may be an early manifestation, the incidence of abnormal bleeding is greater in the more advanced phases. The severity of bleeding varies from petechiae to exsanguination.1Despite wide recognition of this feature of myeloma, its pathogenesis has remained obscure. The etiologic factors most often suggested have been (1) the presence of abnormal plasma proteins impairing normal coagulation,2, 3, 4, 5and (2) deficient clot retraction, of unstated cause.2, 3That the platelet count in myeloma is usually normal has been repeatedly stated by Custer,6Limarzi,2...Bibliography1. JamesMonto TNRW: Multiple myeloma simulating aplastic anemia, to be published. Google Scholar2. Limarzi LR: Diagnostic and therapeutic aspects of multiple myeloma, M. Clin. North America 35: 189-226, 1951. CrossrefMedlineGoogle Scholar3. BayrdHeck EDFJ: Multiple myeloma: a review of 83 proved cases, J. A. M. A. 133: 147-157, 1947. CrossrefMedlineGoogle Scholar4. BernardIncemanZaraChristel JSMD: La dysglobulinemie maligne hemorragipare, Rev. d'hémat 7: 264-295, 1952. MedlineGoogle Scholar5. AndreDreyfusJacobLey RBSG: Sur les formes hémorragiques des myelomes, Rev. d'hémat. 7: 296-305, 1952. MedlineGoogle Scholar6. Custer RP: An atlas of the blood and bone marrow, 1949, W. B. Saunders Co., Philadelphia, p. 89. Google Scholar7. RosenthalVogel NP: Value of the sternal puncture in the diagnosis of multiple myeloma, J. Mt. Sinai Hosp. 4: 1001-1019, 1938. Google Scholar8. Wintrobe MM: Clinical hematology, 3rd Ed., 1951, Lea and Febiger, Philadelphia. Google Scholar9. Magnus-Levy A: Multiple myelome (XII), Acta med. Scandinav. 95: 217-280, 1938. CrossrefGoogle Scholar10. SchwarzArmstrongLoefflerMavrelis SOBEEW: Diffuse plasma cell myelosis: report of a case in which it simulated aplastic anemia on postmortem examination, Arch. Path. 45: 380-384, 1948. Google Scholar11. Begemann H: Myelome und aplastische Anaemie (Panmyelophthise), Ärztl. Forsch. 2: 146-151, 1948. MedlineGoogle Scholar12. AggelerHowardLucia PMJSP: Platelet counts and platelet function, Blood 1: 472-496, 1946. CrossrefMedlineGoogle Scholar13. BarrReaderWheeler DPGGCH: Cryoglobulinemia. I. Report of two cases with a discussion of clinical manifestations, incidence and significance, Ann. Int. Med. 32: 6-29, 1950. LinkGoogle Scholar14. LernerWatson ABCJ: Studies of cryoglobulins. I. Unusual purpura associated with the presence of a high concentration of cryoglobulin (cold precipitable serum globulin), Am. J. M. Sc. 214: 410-415, 1947. CrossrefMedlineGoogle Scholar15. LernerGreenberg ABGR: A homomolecular serum protein with anomalous solubilities, J. Biol. Chem. 162: 429-439, 1946. CrossrefMedlineGoogle Scholar16. AbramsCohenMeyer APPOO: The physical properties of a cryoglobulin obtained from lymph nodes and serum of a case of lymphosarcoma, J. Biol. Chem. 181: 237-245, 1949. CrossrefMedlineGoogle Scholar17. Rorvik K: Cryoglobulinemia: a survey and case report, Acta med. Scandinav. 137: 390-401, 1950. CrossrefMedlineGoogle Scholar18. HayesBennettHeck DWWAFJ: Extramedullar lesions in multiple myeloma, Arch. Path. 53: 262-272, 1952. Google Scholar19. Waldenstrom J: Incipient myelomatosis or "essential" hyperglobulinemia with fibrinogenopenia—a new syndrome? Acta med. Scandinav. 117: 216-247, 1944. CrossrefGoogle Scholar20. Ranstrøm S: On terms "essential hyperglobulinemia" and "premyeloma," Acta med. Scandinav. 124: 134-147, 1946. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Received for publication May 25, 1953.From the Division of Hematology and the Department of Laboratories, Henry Ford Hospital, Detroit, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Role of Platelets in Cancer-Related Bleeding Risk: A Systematic ReviewCancer-associated thromboembolism: antithrombotic management of hospitalized patientsPreoperative embolization in spinal tumour surgery: Enhancing its effectivenessAntithrombotic Therapy in Patients With Thrombocytopenic CancerHemostatic Abnormalities in Multiple Myeloma and Related DisordersUrinary Calculi in Hypercalcemic StatesIg A · K type myeloma with severe postextraction bleedingSome Extrarenal Diseases Associated with Renal Stone or NephrocalcinosisParaproteinämische HämoblastosenBIBLIOGRAPHYIrregular Blood CoagulationParaproteinemia in the lymphomasCoagulation studies in different types of myeloma1HEMORRHAGE IN SURGERY IN MYELOFIBROSIS, MULTIPLE MYELOMA, LEUKEMIA, AND LYMPHOMAS*ON-LINE DIGITAL COMPUTER USED IN BIOLOGICAL EXPERIMENTS AND MODELINGRENAL ASPECTS OF MYELOMATOSISPlasma-Cell MyelomaCase 45261Chronic lymphocytic leukemia associated with dysproteinemia and acquired hemolytic anemiaSt�rungen der Blutgerinnung beim PlasmocytomGastrointestinal Hemorrhage (Excluding Peptic Ulcer and Esophageal Varices)Seltene Form einer Paraproteinose 1 December 1953Volume 39, Issue 6Page: 1281-1287KeywordsHematology and oncologyHemorrhageMultiple myelomaMyelomaPathogenesisPlasma proteinsPlatelets ePublished: 1 December 2008 Issue Published: 1 December 1953 PDF downloadLoading ...