Physiologically based pharmacokinetic modelling of the three‐step metabolism of pyrimidine using¹³C‐uracil as an<i>in vivo</i>probe

Abstract

A PBPK model to describe (13)CO2 exhalation after orally administered [2-(13)C]uracil was successfully developed. Using [2-(13)C]uracil as a probe, this model could be useful in identifying DPD-deficient patients at risk of 5-fluorouracil toxicity.