The Uracil Breath Test in the Assessment of Dihydropyrimidine Dehydrogenase Activity: Pharmacokinetic Relationship between Expired 13CO2 and Plasma [2-13C]Dihydrouracil

Lori K. Mattison, Jeanne Fourie, Yukihiro Hirao, +5

Clinical Cancer Research

High performance liquid chromatographic methods for the determination of aripiprazole with ultraviolet detection in rat plasma and brain: Application to the pharmacokinetic study

Yoshihiko Shimokawa, Hitoshi Akiyama, Eiji Kashiyama, +2

Journal of Chromatography B

Pharmacological StudyMedicinePharmacokinetic StudyAnalytical ChemistryPharmacotherapy +6

Mechanism of Hydroxyl Radical Scavenging by Rebamipide: Identification of Mono-hydroxylated Rebamipide as a Major Reaction Product

Kazushi Sakurai, Hiroyuki Sasabe, Toshihisa Koga, +1

Free Radical Research

Lipid PeroxidationMono-hydroxylated RebamipideReagentRedox BiologyOxidative Stress +14

Toxicological Evaluation of Acyl Glucuronides of Nonsteroidal Anti-Inflammatory Drugs Using Human Embryonic Kidney 293 Cells Stably Expressing Human UDP-Glucuronosyltransferase and Human Hepatocytes

Toshihisa Koga, Ryoichi Fujiwara, Miki Nakajima, +1

Drug Metabolism and Disposition

N-Glycosylation plays a role in protein folding of human UGT1A9

Miki Nakajima, Toshihisa Koga, Haruko SAKAI, +3

Biochemical Pharmacology

Human Ugt1a9Protein FunctionBiochemistryProtein AssemblyProtein Folding +6

Prediction of drug intestinal absorption in human using the Ussing chamber system: A comparison of intestinal tissues from animals and humans

Masateru Miyake, Toshihisa Koga, Satoshi Kondo, +4

European Journal of Pharmaceutical Sciences

Gastrointestinal PharmacologyMedicineBioanalysisForensic ToxicologyGastroenterology +11

Physiologically based pharmacokinetic modelling of the three‐step metabolism of pyrimidine using¹³C‐uracil as an<i>in vivo</i>probe

Suminobu Ito, Takeshi Kawamura, Makoto Inada, +6

British Journal of Clinical Pharmacology

Liquid chromatography–tandem mass spectrometry method for determining tolvaptan and its nine metabolites in rat serum: application to a pharmacokinetic study

Masayuki Furukawa, Kenichi Miyata, Chie Kawasome, +5

Archives of Pharmacal Research

Pharmacological StudyBiochemistryMedicineRat SerumBioanalysis +9

Liquid Chromatography-Tandem Mass Spectrometry Methods for Determination of Delamanid in Mouse Plasma and Lung

Yukihiro Hirao, Toshihisa Koga, Noriyuki Koyama, +2

American Journal of Analytical Chemistry

Calibration CurveGas ChromatographyBioanalysisMouse PlasmaToxicology +17

Evaluation of intestinal metabolism and absorption using the Ussing chamber system equipped with intestinal tissue from rats and dogs

Masateru Miyake, Satoshi Kondo, Toshihisa Koga, +5

European Journal of Pharmaceutics and Biopharmaceutics

Animal PhysiologyNutritionIntestinal TissueDigestive PhysiologyAnimal Nutrition +12