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Evidence that leukocyte function-associated antigen-1 is involved in recirculation and homing of human lymphocytes via high endothelial venules.
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1988
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T-regulatory CellHigh Endothelial VenulesImmunologyBlood CellPathologyAntigen ProcessingT CellsHuman LymphocytesImmune SystemImmunotherapyMab Inhibition StudiesHematologyLymphatic SystemCell TransplantationEndothelial Cell PathobiologyAutoimmune DiseaseNormal DonorsAutoimmunityVascular BiologyCell BiologyMedicineLeukocyte Function-associated Antigen-1
We report the results of mAb inhibition studies of human lymphocyte-high endothelial venule interaction in vitro. These studies in which T cells from both normal donors and from a LFA-1-deficient patient were used indicate that in addition to a system of organ-specific 90-kDa "homing" receptors on lymphocytes, LFA-1 is also involved in lymphocyte recirculation and homing.