The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation.

Rapid and efficient site-specific mutagenesis without phenotypic selection.

Thomas A. Kunkel · Proceedings of the National Academy of Sciences · 1985 · 7.3K citations · Full text

Engineering, Reverse Genetics, Efficient Site-specific Mutagenesis +14

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

Nicholas J. Dyson, Peter M. Howley, Karl Münger et al. · Science · 1989 · 3K citations

Rb1 Gene Product, Tumor Biology, Retinoblastoma Gene +13

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

James A. DeCaprio · Cell · 1988 · 1.5K citations

Cancer-associated Virus, Immunology, Pathology +8

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

Peter Whyte, Karen Buchkovich, Jonathan M. Horowitz et al. · Nature · 1988 · 1.4K citations

Adenovirus E1a, Oncogenic Agent, Pathology +9

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

Karl Münger, William C. Phelps, Vivien J. Bubb et al. · Journal of Virology · 1989 · 1.3K citations · Full text

Terminal Differentiation, E7 Genes, Primary Human Keratinocytes +13