The anti‐amnesic and neuroprotective effects of donepezil against amyloid β_25‐35peptide‐induced toxicity in mice involve an interaction with the<i>σ</i>₁receptor

Abstract

The potent anti-amnesic and neuroprotective effects of donepezil against Abeta(25-35)-induced toxicity involve both its cholinergic and sigma(1) agonistic properties. This dual action may explain its sustained activity compared to other ChE inhibitors.