The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

APC mutations occur early during colorectal tumorigenesis

Steven M. Powell, Nathan Zilz, Yasmin Beazer-Barclay et al. · Nature · 1992 · 1.9K citations

Medicine, Genetics, Molecular Genetics +14

Somatic mutations of the <i>APC</i> gene in colorectal tumors: mutation cluster region in the <i>APC</i> gene

Yasuo Mori, Hiroki Nagse, Hiroshi Ando et al. · Human Molecular Genetics · 1992 · 935 citations · Full text

Medicine, Genetics, Oncology +16

Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC

Steven J. Laken, Gloria M. Petersen, Stephen B. Gruber et al. · Nature Genetics · 1997 · 689 citations

Medicine, Genetics, Oncology +14

Alleles of the APC gene: An attenuated form of familial polyposis

Lisa Spirio, Sylviane Olschwang, Joanna Groden et al. · Cell · 1993 · 621 citations · Full text

Life Sciences, Genetics, Molecular Genetics +9

Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

Akseli Hemminki, Ian Tomlinson, David Markie et al. · Nature Genetics · 1997 · 493 citations

Life Sciences, Genetics, Molecular Genetics +14