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The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

Allelic VariantSomatic MutationSomatic VariantGenetic DisorderFamilial Adenomatous PolyposisGeneticsMedicinePathologyMolecular GeneticsDisease Gene IdentificationGermline MutationMolecular DiagnosticsEpigenetics