The power issue: determination of KB or Ki from IC50

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

O. ARUNLAKSHANA, H. O. Schild · British Journal of Pharmacology and Chemotherapy · 1959 · 4K citations · Full text

Medicine, Pharmacology, General Pharmacology +16

Enzyme kinetics; behavior and analysis of rapid equilibrium and steady state enzyme systems

International Journal of Biochemistry · 1994 · 3K citations

Life Sciences, Biochemistry, Chemistry +16

Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.

J. M. van Rossum · PubMed · 1963 · 1.2K citations

Pharmacy, Pharmacokinetics, Pharmacology +14

Analysis of combined drug effects: a new look at a very old problem

Ting‐Chao Chou, Paul Talalay · Trends in Pharmacological Sciences · 1983 · 623 citations

Medicine, Pharmacology, Pharmacodynamics +5