The N‐terminal region of the dopamine D₂receptor, a rhodopsin‐like GPCR, regulates correct integration into the plasma membrane and endocytic routes

Abstract

Shortening of N-terminus or mutation of glycosylation sites located within the N-terminus enhanced receptor internalization but impaired the surface expression of D(2) receptors. The N-terminal region of the D(2) receptor, in a sequence-specific manner, controls the receptor's conformation and integration into the plasma membrane, which determine its subcellular localization, intracellular trafficking and signalling properties.