Methods for qualitative analysis of genetic networks

Abstract

The diagram of interactions of a genetic regulatory network is represented in a natural and intuitive way by Boolean or other discrete models. Based largely on the structure of the network, rather than on more detailed kinetic properties of the system, discrete models are very useful to study the qualitative dynamics of the genetic network. Several methods for analysis of genetic networks combine a basic Boolean model of the diagram of interactions with other techniques, to generate a more realistic biological model. In this mini-tutorial, some of these methods will be briefly reviewed. These include specifying a matrix of transition probabilities, or the construction of a hybrid, piecewise linear model by adding continuous degradation rates.