Glutamine preferentially inhibits T‐helper type 2 cell‐mediated airway inflammation and late airway hyperresponsiveness through the inhibition of cytosolic phospholipase A₂ activity in a murine asthma model

Abstract

Gln was found to be effective in the suppression of Th2-dependent phenotypes and late AHR, and this effect of Gln appeared to be at least partially attributable to its ability to suppress cLPA(2) activity in the airway. Our results suggest that clinical use of Gln for patients with asthma may be beneficial.