AMINO ACID REQUIREMENTS OF HERPES SIMPLEX VIRUS IN HUMAN CELLS

Abstract

Tankersley, Robert W., Jr. (Medical College of Virginia, Richmond). Amino acid requirements of herpes simplex virus in human cells. J. Bacteriol. 87:609-613. 1964.-Progressive infection of human cells minimally infected with herpes simplex virus requires 11 of the amino acids of Eagle's medium, and glutamine. Lysine is not required, but rather exerts a partially inhibitory effect upon virus multiplication. Infected cells deprived of arginine support neither cytopathogenic effects nor virus replication; when arginine is replaced, a prompt and extensive infection follows. The effect of nutritional deficiencies on virus infection is discussed.