Concepedia

Conversion of pepsinogen into pepsin is not a one-step process

Colin W. Dykes, John Kay

Biochemical Journal · 1976 · 63 citations · 6 references

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Abstract

By incubation of pepsinogen with pepstatin at pH2.5, the first 'active' protein generated on activation is trapped in an inactive complex. The first activation peptide liberated has been identified as residues 1-16 from the pepsinogen sequence. This suggests a sequential mechanism rather than a one-step formation of pepsin.

References

6

EFFECT OF PEPSTATIN ON ACID PROTEASES

TAKAAKI AOYAGI, Setsuko Kunimoto, HAJIME MORISHJMA et al. · The Journal of Antibiotics · 1971 · 158 citations · Full text

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Primary structure of porcine pepsin. III. Amino acid sequence of a cyanogen bromide fragment, CB2A, and the complete structure of porcine pepsin.

Patricia Sepulveda, J Marciniszyn, D. Liu et al. · Journal of Biological Chemistry · 1975 · 126 citations · Full text

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Kinetics and Mechanism of Pepsinogen Activation

Jasim M. Al-Janabi, Jean A. Hartsuck, Jordan Tang · Journal of Biological Chemistry · 1972 · 125 citations · Full text

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The Activation of Bovine Pepsinogen

Marianne Harboe, Per Maack Andersen, Bent Foltmann et al. · Journal of Biological Chemistry · 1974 · 66 citations · Full text

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N-terminal sequence of swine pepsinogen and pepsin. The site of pepsinogen activation

V. M. Stepanov, L. A. Baratova, I. B. Pugacheva et al. · Biochemical and Biophysical Research Communications · 1973 · 32 citations

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