Tyrosine kinases Lyn and Syk regulate B cell receptor‐coupled Ca2+ mobilization through distinct pathways.

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

Grzegorz Grynkiewicz, Martin Poenie, Roger Y. Tsien · Journal of Biological Chemistry · 1985 · 21.7K citations · Full text

Natural Sciences, Biochemistry, Chemistry +17

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Elisabetta Polazzi, Ilaria Mengoni, Marco Caprini et al. · Neurosignals · 2012 · 9K citations · Full text

Life Sciences, Neurobiology, Neuroscience +11

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

Jay P. Morgenstern, Hartmut Land · Nucleic Acids Research · 1990 · 2.1K citations · Full text

Pharmacy, Pharmaceutics, Gene Delivery +15

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

Michael J. Berridge, R. M. C. Dawson, C. Peter Downes et al. · Biochemical Journal · 1983 · 2K citations · Full text

Life Sciences, Biochemistry, Entomology +14

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

David B. Straus · Cell · 1992 · 1K citations

Life Sciences, Immunology, Molecular Biology +16