Peroxynitrite and oxidative damage in experimental autoimmune uveitis.

Abstract

In EAU, there was a substantial concentration of peroxynitrite in the photoreceptors. The presence of this oxidant appears to correlate with the pathologic oxidation demonstrated in this area. The photoreceptors are especially prone to radical-induced lipid peroxidation caused by the high concentration of docasahexaenoic acid that is contained in these structures.