Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.

Molecular cloning: A laboratory manual

Prescott L. Deininger · Analytical Biochemistry · 1990 · 86.2K citations

Life Sciences, Molecular Biology, Molecular Genetics +11

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

Randall K. Saiki, David H. Gelfand, Susanne Stoffel et al. · Science · 1988 · 17.2K citations

Life Sciences, Biotechnology, Molecular Biology +12

Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants.

Seth G. N. Grant, Joel Jessee, F R Bloom et al. · Proceedings of the National Academy of Sciences · 1990 · 1.2K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

Gillian M. Griffiths, Claudia Berek, Matti Kaartinen et al. · Nature · 1984 · 534 citations

Life Sciences, Genetics, Immunology +11

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

Patricia J. Gearhart, Nelson D. Johnson, R. Douglas et al. · Nature · 1981 · 503 citations

Life Sciences, Biochemistry, Immunology +12