Succinoxidase

Abstract

MUSCLE, liver and other tissues have been shown [Thunberg, 1909; Batelli and Stern, 1911] to contain a very powerful and remarkably specific enzyme, succinoxidase, which, according to Batelli and Stern, converts succinic into optically inactive malic acid. Einbeck [1914] regarded fumaric and not malic acid as the sole product, but later [1919] showed that the enzyme first converts succinic to fumaric acid and then, by a balanced reaction, to a mixture of fumaric (25 %) and malic (75 %) acids. Dakin [1922] showed that fumaric