Regioselectively controlled synthesis of 3(5)-(trifluoromethyl)pyrazolylbenzenesulfonamides and their effects on a pathological pain model in mice

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

Garrett M. Morris, Ruth Huey, William Lindstrom et al. · Journal of Computational Chemistry · 2009 · 25K citations · Full text

Pharmacy, Bioinformatics, Medicinal Chemistry +13

Comparative Protein Modelling by Satisfaction of Spatial Restraints

Andrej Šali, Tom L. Blundell · Journal of Molecular Biology · 1993 · 13.2K citations

Life Sciences, Biochemistry, Bioinformatics +11

Ethical guidelines for investigations of experimental pain in conscious animals

M. Zimmermann · Pain · 1983 · 7.8K citations

Medicine, Anesthesiology, Animal Sciences +14

Efficient Analysis of Experimental Observations

W. J. Dixon · The Annual Review of Pharmacology and Toxicology · 1980 · 2.2K citations

Public Health, Biostatistics, Pharmacology +7

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17