K-ras Gene Mutation Enhances Motility of Immortalized Airway Cells and Lung Adenocarcinoma Cells via Akt Activation

Analysis of lung tumor initiation and progression using conditional expression of oncogenic <i>K-ras</i>

Erica L. Jackson, Nicholas A. Willis, Kim L. Mercer et al. · Genes & Development · 2001 · 2K citations · Full text

Medicine, Cancer Biology, Oncology +17

Prevalence of ras gene mutations in human colorectal cancers

Johannes L. Bos, Eric R. Fearon, Stanley R. Hamilton et al. · Nature · 1987 · 1.9K citations

Medicine, Genetics, Oncology +14

Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.

John Brognard, Amy S. Clark, Yucheng Ni et al. · PubMed · 2001 · 892 citations

Medicine, Cancer Biology, Oncology +17

The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.

Sylvia Grille, Alfonso Bellacosa, John J. Upson et al. · PubMed · 2003 · 617 citations

Medicine, Cell Biology, Oncology +17

The pathway to signal achievement

Sean E. Egan, Robert A. Weinberg · Nature · 1993 · 563 citations

Education, Educational Psychology, Signal Transduction +1