Mirna Therapeutics (United States)

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

Can Liu, Kevin Kelnar, Bigang Liu et al. · Nature Medicine · 2011 · 1.4K citations · Full text

Microrna Mir-34a Inhibits, Medicine, Stem Cells +11

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

Jennifer A. Lockridge, Lucinda Shaw, Karin S. Blanchard et al. · Nature Biotechnology · 2005 · 1.2K citations

Medicinal Chemistry, Viral Hepatitis, Immunology +9

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

Muhammad S. Beg, Andrew Brenner, Jasgit C. Sachdev et al. · Investigational New Drugs · 2016 · 855 citations · Full text

Tumor Biology, Medicine, Pathology +8

Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours

David S. Hong, Yoon‐Koo Kang, Mitesh J. Borad et al. · British Journal of Cancer · 2020 · 850 citations · Full text

miR-34 – a microRNA replacement therapy is headed to the clinic

Andreas G. Bader · Frontiers in Genetics · 2012 · 721 citations · Full text

Mir-34 –, Pathology, Cancer Biology +19