Lyell Immunopharma (United States)

c-Jun overexpression in CAR T cells induces exhaustion resistance

Rachel C. Lynn, Evan W. Weber, Elena Sotillo et al. · Nature · 2019 · 893 citations · Full text

Life Sciences, Cell Biology, Immunology +16

CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

Jay Y. Spiegel, Shabnum Patel, Lori Muffly et al. · Nature Medicine · 2021 · 572 citations · Full text

Medicine, Hematology, Oncology +17

Avelumab plus axitinib versus sunitinib in advanced renal cell carcinoma: biomarker analysis of the phase 3 JAVELIN Renal 101 trial

Robert J. Motzer, Paul B. Robbins, Thomas Powles et al. · Nature Medicine · 2020 · 522 citations · Full text

Medicine, Oncology, Pharmacology +15

Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma

Marcus Smith Noel, Eileen M. O’Reilly, Brian M. Wolpin et al. · Investigational New Drugs · 2019 · 182 citations · Full text

Medicine, Oncology, Pharmacology +17

Breast Cancers Are Immunogenic: Immunologic Analyses and a Phase II Pilot Clinical Trial Using Mutation-Reactive Autologous Lymphocytes

Journal of Clinical Oncology · 2022 · 177 citations · Full text

Medicine, Immunology, Oncology +17