NĒRx BioSciences (United States)

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

Ke Cong, Min Peng, Arne Nedergaard Kousholt et al. · Molecular Cell · 2021 · 298 citations · Full text

Genome Instability, Natural Sciences, Key Determinant +8

Chemical inhibitor targeting the replication protein A–DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer

Akaash K. Mishra, Silvana S. Dormi, Alaina M. Turchi et al. · Biochemical Pharmacology · 2014 · 56 citations · Full text

Pt-based Chemotherapy, Oncology, Medicine +8

Assessment of prediction methods for protein structures determined by <scp>NMR</scp> in <scp>CASP14</scp> : Impact of <scp>AlphaFold2</scp>

Yuanpeng J. Huang, Ning Zhang, Beate Bersch et al. · Proteins Structure Function and Bioinformatics · 2021 · 51 citations · Full text

Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku–DNA interaction

Navnath S. Gavande, Pamela S. VanderVere-Carozza, Katherine S. Pawelczak et al. · Nucleic Acids Research · 2020 · 44 citations · Full text

Structure-Guided Optimization of Replication Protein A (RPA)–DNA Interaction Inhibitors

Navnath S. Gavande, Pamela S. VanderVere-Carozza, Katherine S. Pawelczak et al. · ACS Medicinal Chemistry Letters · 2020 · 27 citations · Full text