Center for Digital Image Evaluation

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

Nagaraj Kerur, Shin‐ichi Fukuda, Daipayan Banerjee et al. · Nature Medicine · 2017 · 294 citations · Full text

Medicine, Immunology, Ophthalmology +14

Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration

Meenakshi Ambati, Ivana Apicella, Shao-Bin Wang et al. · Proceedings of the National Academy of Sciences · 2021 · 72 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16

Cytoplasmic synthesis of endogenous <i>Alu</i> complementary DNA via reverse transcription and implications in age-related macular degeneration

Shin‐ichi Fukuda, Akhil Varshney, Benjamin J. Fowler et al. · Proceedings of the National Academy of Sciences · 2021 · 64 citations · Full text

Medicine, Genetics, Molecular Biology +15

DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs

Shao-Bin Wang, Siddharth Narendran, Shuichiro Hirahara et al. · Science Immunology · 2021 · 51 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

<i>Alu</i> complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity

Shin‐ichi Fukuda, Siddharth Narendran, Akhil Varshney et al. · Science Advances · 2021 · 51 citations · Full text

Medicine, Genetics, Molecular Biology +13