Concepedia

<i>Alu</i> complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity

Shin‐ichi Fukuda, Siddharth Narendran, Akhil Varshney, Yosuke Nagasaka, Shao-Bin Wang, Kameshwari Ambati, Ivana Apicella, Felipe Pereira, Benjamin J. Fowler, Tetsuhiro Yasuma,

Science Advances · 2021 · 51 citations · 51 references

DOIFull text

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Abstract

cDNA toxicity, identifying inflammasome activation as the terminal effector of RPE degeneration.

References

51

Mfold web server for nucleic acid folding and hybridization prediction

Michael Zuker · Nucleic Acids Research · 2003 · 13.6K citations · Full text

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Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Lijun Sun, Jiaxi Wu, Fenghe Du et al. · Science · 2012 · 4.8K citations

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Mitochondrial DNA stress primes the antiviral innate immune response

A. Phillip West, William Khoury-Hanold, Matthew Staron et al. · Nature · 2015 · 1.9K citations · Full text

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Human L1 Retrotransposon Encodes a Conserved Endonuclease Required for Retrotransposition

Qinghua Feng, John V. Moran, Haig H. Kazazian et al. · Cell · 1996 · 1.2K citations · Full text

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High Frequency Retrotransposition in Cultured Mammalian Cells

John V. Moran, Susan E. Holmes, Thierry Naas et al. · Cell · 1996 · 1K citations · Full text

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