Concepedia

Wild-type Ras Function

Wild-Type RAS Function is a molecular biology construct denoting the normal, non-mutated activity of RAS proteins in regulating cell signaling pathways that control proliferation, differentiation, and survival through controlled GTPase cycling.

314

Publications

24.6K

Citations

1.9K

Authors

708

Institutions

Publications per year

2017–2026

68

Parents

Publications

314

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

Shonna A. Moodie, Berthe M. Willumsen, Michael J. Weber et al. · Science · 1993 · 986 citations

, , +15

K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors

David B. Whyte, Paul T. Kirschmeier, Tish Hockenberry et al. · Journal of Biological Chemistry · 1997 · 881 citations · Full text

, , +16

Inhibition of NIH 3T3 Cell Proliferation by a Mutant <i>ras</i> Protein with Preferential Affinity for GDP

Larry A. Feig, Geoffrey M. Cooper · Molecular and Cellular Biology · 1988 · 755 citations · Full text

, , +17

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

Gangfeng Xu, Boris K. Lin, Kazuma Tanaka et al. · Cell · 1990 · 693 citations

, , +15

Biological properties of human c-Ha-ras1 genes mutated at codon 12

Peter H. Seeburg, Wendy W. Colby, Daniel J. Capon et al. · Nature · 1984 · 587 citations

, , +14

1–5 of 314

Authors

1.9K

  1. CJ
    Channing J. Der

    University of North Carolina at Chapel Hill, United States

    10 publications · 967 citations

    10

    h-index

  2. MW
    Michael Wigler

    Cold Spring Harbor Laboratory, United States

    8 publications · 811 citations

    8

    h-index

  3. VH
    Volker Heinemann

    Ludwig-Maximilians-Universität München, Germany

    7 publications · 904 citations

    7

    h-index

  4. AD
    Adrienne D. Cox

    University of North Carolina at Chapel Hill, United States

    7 publications · 572 citations

    7

    h-index

  5. LA
    Larry A. Feig

    Tufts University, United States

    7 publications · 1.9K citations

    7

    h-index

1–5 of 1.9K

Institutions

708

  1. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    14 h-index

    54 publications

    4.3K citations

  2. Memorial Sloan Kettering Cancer Center

    New York, United States

    10 h-index

    27 publications

    3.1K citations

  3. UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, United States

    10 h-index

    25 publications

    1.8K citations

  4. New York University

    New York, United States

    9 h-index

    26 publications

    2K citations

  5. Dana-Farber Cancer Institute

    Boston, United States

    9 h-index

    18 publications

    1.7K citations

  6. Cold Spring Harbor Laboratory

    Cold Spring Harbor, United States

    8 h-index

    38 publications

    3.8K citations

  7. National Cancer Institute

    Bethesda, United States

    8 h-index

    22 publications

    1.8K citations

  8. Center for Cancer Research

    Bethesda, United States

    7 h-index

    33 publications

    3.2K citations

1–8 of 708

Venues

  1. Molecular and Cellular Biology

    MCB · 45 publications · 3.9K citations

    31

    h-index

  2. Journal of Biological Chemistry

    JBC · 30 publications · 2.7K citations

    23

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 20 publications · 2.6K citations

    20

    h-index

  4. PubMed

    Repository · 21 publications · 2K citations

    17

    h-index

  5. Journal of Clinical Oncology

    11 publications · 492 citations

    11

    h-index

1–5