Concepedia

Vector Yield Optimization

Vector Yield Optimization is a methodological framework in gene therapy manufacturing that systematically enhances the production efficiency and output of viral vectors by refining bioprocess parameters, cellular systems, and vector design to maximize functional vector titers while maintaining quality and scalability.

23

Publications

1.2K

Citations

132

Authors

50

Institutions

Publications per year

2017–2026

11

Parents

Publications

23

High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency

Eduard Ayuso, Federico Mingozzi, Joel Montané et al. · Gene Therapy · 2009 · 278 citations

, , +13

Requirements for Efficient Production and Transduction of Human Immunodeficiency Virus Type 1-Based Vectors

Mehdi Gasmi, Jacqueline M. Glynn, Mingjie Jin et al. · Journal of Virology · 1999 · 132 citations · Full text

, , +16

Creation of a High-Yield AAV Vector Production Platform in Suspension Cells Using a Design-of-Experiment Approach

Huiren Zhao, Ki Jeong Lee, Mark Daris et al. · Molecular Therapy — Methods & Clinical Development · 2020 · 97 citations · Full text

, , +17

Optimization of the Generation and Propagation of Gutless Adenoviral Vectors

Kiran Sakhuja, P. Seshidhar Reddy, Shanthi Ganesh et al. · Human Gene Therapy · 2003 · 73 citations

, , +13

Large-scale Clinical-grade Retroviral Vector Production in a Fixed-Bed Bioreactor

Xiuyan Wang, Malgorzata Olszewska, Jinrong Qu et al. · Journal of Immunotherapy · 2015 · 71 citations · Full text

, , +13

1–5 of 23

Authors

132

  1. AK
    Amine Kamen

    Biotechnology Research Institute, Canada

    2 publications · 55 citations

    2

    h-index

  2. NC
    Nathalie Clément

    University of Florida, United States

    1 publications · 20 citations

    1

    h-index

  3. SS
    Seunghyeon Shin

    Korea Advanced Institute of Science and Technology, South Korea

    1 publications · 23 citations

    1

    h-index

  4. JA
    James A. Williams

    Nature Technology Corporation (United States), United States

    1 publications · 44 citations

    1

    h-index

  5. XW
    Xiuyan Wang

    Memorial Sloan Kettering Cancer Center, United States

    1 publications · 71 citations

    1

    h-index

1–5 of 132

Institutions

50

  1. Advanced Vision Institute

    Williamsburg, United States

    1 h-index

    2 publications

    146 citations

  2. Université de Montréal

    Montreal, Canada

    1 h-index

    2 publications

    64 citations

  3. St. Jude Children's Research Hospital

    Memphis, United States

    1 h-index

    7 publications

    189 citations

  4. Universitat Autònoma de Barcelona

    Cerdanyola del Vallès, Spain

    1 h-index

    5 publications

    1.4K citations

  5. Chung Shan Medical University

    Taichung, Taiwan

    1 h-index

    1 publications

    25 citations

  6. Helmholtz Zentrum München

    Munich, Germany

    1 h-index

    1 publications

    67 citations

  7. Memorial Sloan Kettering Cancer Center

    New York, United States

    1 h-index

    2 publications

    142 citations

  8. Arsenal Medical (United States)

    Watertown, United States

    1 h-index

    9 publications

    117 citations

1–8 of 50

Venues

  1. 4

    h-index

  2. Biotechnology and Bioengineering

    3 publications · 99 citations

    3

    h-index

  3. Human Gene Therapy

    2 publications · 108 citations

    2

    h-index

  4. Journal of Virology

    JVI · 2 publications · 187 citations

    2

    h-index

  5. Gene Therapy

    2 publications · 332 citations

    2

    h-index

1–5