Concepedia

Vector Backbone Effects

Vector Backbone Effects is a phenomenon in molecular biology wherein the non-transcribed regions of a gene delivery vector influence the level, stability, or regulation of transgene expression through epigenetic, transcriptional, or post-transcriptional mechanisms intrinsic to the vector's structural architecture.

28

Publications

2.2K

Citations

153

Authors

50

Institutions

Publications per year

2017–2026

6

Parents

Publications

28

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells.

Isabelle Rivière, Katja Brose, Richard Mulligan · Proceedings of the National Academy of Sciences · 1995 · 375 citations · Full text

, , +16

Linear transgene constructs lacking vector backbone sequences generate low-copy-number transgenic plants with simple integration patterns

Xiang‐Dong Fu, Le Tan Duc, Stefania Fontana et al. · Transgenic Research · 2000 · 225 citations

, , +17

Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors.

Christina Addison, Mary Hitt, D Kunsken et al. · Journal of General Virology · 1997 · 155 citations

, , +16

Inhibition of HIV-1 infection by lentiviral vectors expressing pol III-promoted anti-HIV RNAs

Ming-Jie Li, Gerhard Bauer, Alessandro Michienzi et al. · Molecular Therapy · 2003 · 155 citations · Full text

, , +17

Concerted Assembly and Cloning of Multiple DNA Segments Using In Vitro Site-Specific Recombination: Functional Analysis of Multi-Segment Expression Clones

David L. Cheo, Steven A. Titus, Devon R. Byrd et al. · Genome Research · 2004 · 139 citations · Full text

, , +17

1–5 of 28

Authors

153

  1. CA
    Christina Addison

    Ottawa Hospital, Canada

    2 publications · 249 citations

    2

    h-index

  2. FL
    Frank L. Graham

    McMaster University, Canada

    2 publications · 249 citations

    2

    h-index

  3. JJ
    John J. Rossi

    City of Hope, United States

    2 publications · 230 citations

    2

    h-index

  4. YH
    Yunwen Huo

    Stanford University, United States

    1 publications · 49 citations

    1

    h-index

  5. JW
    Jianbin Wang

    Tsinghua University, China

    1 publications · 134 citations

    1

    h-index

1–5 of 153

Institutions

50

  1. Beckman Research Institute

    Duarte, United States

    2 h-index

    12 publications

    1.7K citations

  2. City of Hope

    Lancaster, United States

    2 h-index

    12 publications

    1.7K citations

  3. McMaster University

    Hamilton, Canada

    2 h-index

    8 publications

    996 citations

  4. Heidelberg University

    Heidelberg, Germany

    1 h-index

    1 publications

    18 citations

  5. Wake Forest University

    Winston-Salem, United States

    1 h-index

    3 publications

    87 citations

  6. University of Louisville

    Louisville, United States

    1 h-index

    1 publications

    53 citations

  7. UConn Health

    Farmington, United States

    1 h-index

    1 publications

    75 citations

  8. Defense Threat Reduction Agency

    Fort Belvoir, United States

    1 h-index

    1 publications

    139 citations

1–8 of 50

Venues

  1. Journal of Virology

    JVI · 2 publications · 123 citations

    2

    h-index

  2. Nucleic Acids Research

    2 publications · 128 citations

    2

    h-index

  3. Scientific Reports

    2 publications · 54 citations

    2

    h-index

  4. Transgenic Research

    2 publications · 254 citations

    2

    h-index

  5. Molecular Therapy

    2 publications · 204 citations

    2

    h-index

1–5