Concepedia

Vector Backbone Architecture

Vector Backbone Architecture is a foundational plasmid or viral vector framework that serves as the structural and functional scaffold of an expression vector, distinguished by its conserved genetic elements—such as origin of replication, selectable markers, and promoter regions—engineered to enable the stable maintenance, propagation, and regulated expression of inserted transgenes in host cells.

16

Publications

1.7K

Citations

109

Authors

44

Institutions

Publications per year

2017–2026

4

Parents

Publications

16

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells.

Isabelle Rivière, Katja Brose, Richard Mulligan · Proceedings of the National Academy of Sciences · 1995 · 375 citations · Full text

, , +16

Linear transgene constructs lacking vector backbone sequences generate low-copy-number transgenic plants with simple integration patterns

Xiang‐Dong Fu, Le Tan Duc, Stefania Fontana et al. · Transgenic Research · 2000 · 225 citations

, , +17

Inhibition of Human Immunodeficiency Virus Type 1 Entry in Cells Expressing gp41-Derived Peptides

Marc Egelhofer, Gunda Brandenburg, Holger Martinius et al. · Journal of Virology · 2003 · 146 citations · Full text

, , +17

Concerted Assembly and Cloning of Multiple DNA Segments Using In Vitro Site-Specific Recombination: Functional Analysis of Multi-Segment Expression Clones

David L. Cheo, Steven A. Titus, Devon R. Byrd et al. · Genome Research · 2004 · 139 citations · Full text

, , +17

Simultaneous Expression of Multiple Proteins Under a Single Promoter in <i>Caenorhabditis elegans</i> via a Versatile 2A-Based Toolkit

Arnaud Ahier, Sophie Jarriault · Genetics · 2013 · 129 citations

, , +13

1–5 of 16

Authors

109

  1. DV
    Dorotheé von Laer

    Innsbruck Medical University, Austria

    1 publications · 146 citations

    1

    h-index

  2. MB
    Marie Borggren

    University of Southern Denmark, Denmark

    1 publications · 20 citations

    1

    h-index

  3. SJ
    Sophie Jarriault

    Inserm, France

    1 publications · 129 citations

    1

    h-index

  4. AF
    Anders Fomsgaard

    Statens Serum Institut, Denmark

    1 publications · 20 citations

    1

    h-index

  5. AS
    Ada Serena Marletta

    Università degli Studi del Piemonte Orientale “Amedeo Avogadro”, Italy

    1 publications · 104 citations

    1

    h-index

1–5 of 109

Institutions

44

  1. John Innes Centre

    Norwich, United Kingdom

    2 h-index

    13 publications

    2.3K citations

  2. Nara Institute of Science and Technology

    Ikoma, Japan

    1 h-index

    2 publications

    132 citations

  3. Whitehead Institute for Biomedical Research

    Cambridge, United States

    1 h-index

    3 publications

    1.1K citations

  4. Medizinische Hochschule Hannover

    Hanover, Germany

    1 h-index

    2 publications

    292 citations

  5. St. Jude Children's Research Hospital

    Memphis, United States

    1 h-index

    1 publications

    63 citations

  6. University of Minnesota

    Minneapolis, United States

    1 h-index

    6 publications

    378 citations

  7. Defense Threat Reduction Agency

    Fort Belvoir, United States

    1 h-index

    1 publications

    139 citations

  8. Tamil Nadu Agricultural University

    Coimbatore, India

    1 h-index

    2 publications

    450 citations

1–8 of 44

Venues

  1. Transgenic Research

    2 publications · 254 citations

    2

    h-index

  2. Molecular Breeding

    1 publications · 79 citations

    1

    h-index

  3. Journal of Clinical Microbiology

    JCM · 1 publications · 81 citations

    1

    h-index

  4. Genetics

    1 publications · 129 citations

    1

    h-index

  5. Journal of Virology

    JVI · 1 publications · 146 citations

    1

    h-index

1–5