Concepedia

Vasodilator Tolerance

Vasodilator Tolerance is a physiological phenomenon characterized by the diminished responsiveness to vasodilator agents over time, necessitating higher doses to achieve the same therapeutic effect, due to adaptive mechanisms such as neurohormonal activation and vascular smooth muscle desensitization.

118

Publications

7.6K

Citations

497

Authors

175

Institutions

Publications per year

2017–2026

3

Parents

Publications

118

Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction.

Claes Frostell, M D Fratacci, John C. Wain et al. · Circulation · 1991 · 1.1K citations · Full text

, , +16

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.

Thomas Münzel, Hassan Sayegh, Bruce Α. Freeman et al. · Journal of Clinical Investigation · 1995 · 655 citations · Full text

, , +15

MECHANISM OF TOLERANCE DEVELOPMENT TO ORGANIC NITRATES

Philip Needleman, Eugene M. Johnson · Journal of Pharmacology and Experimental Therapeutics · 1973 · 499 citations

, , +10

Long-term response to calcium-channel blockers in non-idiopathic pulmonary arterial hypertension

David Montani, L. Savale, Delphine Natali et al. · European Heart Journal · 2010 · 359 citations · Full text

, , +16

Nitrite Infusion in Humans and Nonhuman Primates

André Dejam, Christian J. Hunter, Carole K. Tremonti et al. · Circulation · 2007 · 334 citations

, , +13

1–5 of 118

Authors

497

  1. TM
    Thomas Münzel

    Johannes Gutenberg University Mainz, Germany

    6 publications · 1.3K citations

    6

    h-index

  2. DG
    David G. Harrison

    Emory University, United States

    3 publications · 936 citations

    3

    h-index

  3. HL
    H L Fung

    University at Buffalo, State University of New York, United States

    3 publications · 428 citations

    3

    h-index

  4. SH
    S. Holzmann

    University of Graz, Austria

    3 publications · 80 citations

    3

    h-index

  5. JD
    John D. Horowitz

    Queen Elizabeth Hospital, Australia

    3 publications · 98 citations

    3

    h-index

1–5 of 497

Institutions

175

  1. Emory University

    Atlanta, United States

    5 h-index

    11 publications

    3K citations

  2. University of Freiburg

    Freiburg im Breisgau, Germany

    4 h-index

    14 publications

    1.1K citations

  3. Parker Hannifin (United States)

    Cleveland, United States

    3 h-index

    3 publications

    444 citations

  4. University of Graz

    Graz, Austria

    3 h-index

    5 publications

    136 citations

  5. Inserm

    Paris, France

    3 h-index

    15 publications

    3.9K citations

  6. Queen's University

    Kingston, Canada

    3 h-index

    9 publications

    168 citations

  7. University of California, Los Angeles

    Los Angeles, United States

    3 h-index

    15 publications

    584 citations

  8. Linköping University

    Linköping, Sweden

    3 h-index

    11 publications

    371 citations

1–8 of 175

Venues

  1. Circulation

    10 publications · 2.4K citations

    10

    h-index

  2. Journal of Cardiovascular Pharmacology

    10 publications · 249 citations

    10

    h-index

  3. PubMed

    Repository · 9 publications · 175 citations

    9

    h-index

  4. 7

    h-index

  5. British Journal of Pharmacology

    BJP · 7 publications · 194 citations

    7

    h-index

1–5