Concepedia

Variable Region Grafting

Variable Region Grafting is a recombinant antibody engineering technique in which the antigen-binding variable regions of a non-human antibody are transplanted into the corresponding framework of a human antibody to reduce immunogenicity while preserving antigen specificity.

11

Publications

507

Citations

70

Authors

22

Institutions

Publications per year

2017–2026

1

Variants

Complementarity-determining Region Grafting

Parents

Publications

11

Reshaping a therapeutic CD4 antibody.

Scott D. Gorman, Mike Clark, E. G. Routledge et al. · Proceedings of the National Academy of Sciences · 1991 · 96 citations

, , +12

A comparison of two murine monoclonal antibodies humanized by CDR-grafting and variable domain resurfacing

Michael Roguska, Jan T. Pedersen, Andrew Henry et al. · Protein Engineering Design and Selection · 1996 · 67 citations · Full text

, , +17

Genetically engineered antibodies: progress and prospects.

Ann Wright, Seung‐Uon Shin, Sherie L. Morrison · PubMed · 1992 · 66 citations

, , +17

Generation of a humanized anti-glypican 3 antibody by CDR grafting and stability optimization

Kiyotaka Nakano, Takahiro Ishiguro, Hiroko Konishi et al. · Anti-Cancer Drugs · 2010 · 64 citations

, , +17

Impact of IgG subclass on molecular properties of monoclonal antibodies

Yu Tang, Paul Cain, Victor Anguiano et al. · mAbs · 2021 · 59 citations · Full text

, , +17

1–5 of 11

Authors

70

  1. SL
    Sherie L. Morrison

    University of California, Los Angeles, United States

    2 publications · 79 citations

    2

    h-index

  2. QG
    Qingcheng Guo

    Second Military Medical University, China

    1 publications · 25 citations

    1

    h-index

  3. AR
    Anthony R. Rees

    University of Bath, United Kingdom

    1 publications · 67 citations

    1

    h-index

  4. JT
    Jan T. Pedersen

    Lundbeck (Denmark), Denmark

    1 publications · 67 citations

    1

    h-index

  5. SS
    Sandra Soares

    XOMA (United States), United States

    1 publications · 50 citations

    1

    h-index

1–5 of 70

Institutions

22

  1. University of California, Los Angeles

    Los Angeles, United States

    2 h-index

    2 publications

    79 citations

  2. Second Military Medical University

    Shanghai, China

    1 h-index

    10 publications

    250 citations

  3. Synta Pharmaceuticals (United States)

    Lexington, United States

    1 h-index

    1 publications

    59 citations

  4. Chugai Pharma (United States)

    Berkeley Heights, United States

    1 h-index

    1 publications

    64 citations

  5. South China University of Technology

    Guangzhou, China

    1 h-index

    2 publications

    50 citations

  6. Advanced Bioscience Laboratories (United States)

    Rockville, United States

    1 h-index

    1 publications

    67 citations

  7. Wellcome Trust

    London, United Kingdom

    1 h-index

    2 publications

    26 citations

  8. Cancer Institute (WIA)

    Chennai, India

    1 h-index

    9 publications

    225 citations

1–8 of 22

Venues

  1. Protein Engineering Design and Selection

    PEDS · 3 publications · 131 citations

    3

    h-index

  2. mAbs

    2 publications · 84 citations

    2

    h-index

  3. Anti-Cancer Drugs

    1 publications · 64 citations

    1

    h-index

  4. PubMed

    Repository · 1 publications · 66 citations

    1

    h-index

  5. Gene

    1 publications · 13 citations

    1

    h-index

1–5