Concepedia

Upf3 Function

Upf3 Function is a molecular mechanism within the nonsense-mediated decay pathway that serves as an adaptor protein responsible for bridging the exon junction complex to the core decay machinery, thereby distinguishing transcripts targeted for degradation through its specific interaction with Upf2 and the ribosome during translation termination.

42

Publications

4.2K

Citations

268

Authors

102

Institutions

Publications per year

2017–2026

13

Parents

Publications

42

PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components

Zhipeng Ma, Peipei Zhu, Hui Shi et al. · Nature · 2019 · 512 citations

, , +8

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity

Hala Chamieh, Lionel Ballut, Fabien Bonneau et al. · Nature Structural & Molecular Biology · 2007 · 345 citations

, , +15

Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation

Patrick Tarpey, F. Lucy Raymond, Lam Son Nguyen et al. · Nature Genetics · 2007 · 294 citations · Full text

, , +12

Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets

Jan Rehwinkel, Ivica Letunić, Jeroen Raes et al. · RNA · 2005 · 262 citations · Full text

, , +16

Nonsense-Mediated Decay of Alternative Precursor mRNA Splicing Variants Is a Major Determinant of the <i>Arabidopsis</i> Steady State Transcriptome

Gabriele Drechsel, André Kahles, Anil K Kesarwani et al. · The Plant Cell · 2013 · 237 citations · Full text

, , +17

1–5 of 42

Authors

268

  1. JG
    Jozef Gécz

    The University of Adelaide, Australia

    4 publications · 625 citations

    4

    h-index

  2. LH
    Lulu Huang

    Nanjing Agricultural University, China

    4 publications · 497 citations

    4

    h-index

  3. MW
    Miles Wilkinson

    The University of Texas MD Anderson Cancer Center, United States

    4 publications · 497 citations

    4

    h-index

  4. AE
    Andreas E. Kulozik

    Heidelberg University, Germany

    3 publications · 322 citations

    3

    h-index

  5. WC
    Wai-Kin Chan

    The University of Texas MD Anderson Cancer Center, United States

    3 publications · 418 citations

    3

    h-index

1–5 of 268

Institutions

102

  1. European Molecular Biology Laboratory

    Heidelberg, Germany

    5 h-index

    14 publications

    2K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    14 publications

    2.4K citations

  3. University of California San Diego

    San Diego, United States

    4 h-index

    28 publications

    3.5K citations

  4. The University of Adelaide

    Adelaide, Australia

    4 h-index

    8 publications

    1.3K citations

  5. Heidelberg University

    Heidelberg, Germany

    4 h-index

    12 publications

    1.4K citations

  6. The University of Texas MD Anderson Cancer Center

    Houston, United States

    3 h-index

    6 publications

    796 citations

  7. Inserm

    Paris, France

    3 h-index

    10 publications

    1K citations

  8. University of Wisconsin–Madison

    Madison, United States

    3 h-index

    8 publications

    728 citations

1–8 of 102

Venues

  1. Nucleic Acids Research

    3 publications · 114 citations

    3

    h-index

  2. RNA

    3 publications · 472 citations

    3

    h-index

  3. Nature Structural & Molecular Biology

    3 publications · 670 citations

    3

    h-index

  4. Molecular and Cellular Biology

    MCB · 3 publications · 252 citations

    3

    h-index

  5. The EMBO Journal

    3 publications · 217 citations

    3

    h-index

1–5