Concepedia

Two-step Mendelian Randomization

Two-Step Mendelian Randomization is a causal inference method in genetics that extends standard Mendelian randomization by first identifying genetic variants associated with a modifiable exposure and then separately assessing their association with an outcome, thereby distinguishing direct from indirect causal effects through a two-stage analytic framework.

31

Publications

1.8K

Citations

228

Authors

118

Institutions

Publications per year

2017–2026

28

Variants

Two-step Mr

Parents

Publications

31

Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

Caroline L. Relton, George Davey Smith · International Journal of Epidemiology · 2012 · 604 citations · Full text

, , +17

Bidirectional Mendelian Randomization and Multiphenotype GWAS Show Causality and Shared Pathophysiology Between Depression and Type 2 Diabetes

Jared G. Maina, Zhanna Balkhiyarova, Arie Nouwen et al. · Diabetes Care · 2023 · 164 citations · Full text

, , +17

Mendelian randomization supports causality between maternal hyperglycemia and epigenetic regulation of leptin gene in newborns

Catherine Allard, Véronique Desgagné, Johane Patenaude et al. · Epigenetics · 2015 · 140 citations · Full text

, , +17

The impact of education inequality on rheumatoid arthritis risk is mediated by smoking and body mass index: Mendelian randomization study

Sizheng Steven Zhao, Michael V. Holmes, Jie Zheng et al. · Lara D. Veeken · 2021 · 94 citations · Full text

, , +17

Prenatal Nutrition, Epigenetics and Schizophrenia Risk: Can We Test Causal Effects?

James B. Kirkbride, Ezra Susser, Marija Kundaković et al. · Epigenomics · 2012 · 88 citations

, , +17

1–5 of 31

Authors

228

  1. GD
    George Davey Smith

    University of Bristol, United Kingdom

    5 publications · 833 citations

    5

    h-index

  2. CL
    Caroline L. Relton

    University of Bristol, United Kingdom

    5 publications · 833 citations

    5

    h-index

  3. TR
    Tom R. Gaunt

    University of Bristol, United Kingdom

    3 publications · 97 citations

    3

    h-index

  4. DG
    Dipender Gill

    Imperial College London, United Kingdom

    2 publications · 71 citations

    2

    h-index

  5. RE
    Robyn E. Wootton

    University of Bristol, United Kingdom

    2 publications · 98 citations

    2

    h-index

1–5 of 228

Institutions

118

  1. University of Bristol

    Bristol, United Kingdom

    9 h-index

    48 publications

    3.1K citations

  2. University Hospitals Bristol NHS Foundation Trust

    Bristol, United Kingdom

    3 h-index

    8 publications

    370 citations

  3. Imperial College London

    London, United Kingdom

    3 h-index

    10 publications

    1.3K citations

  4. Shanxi Medical University

    Taiyuan, China

    2 h-index

    4 publications

    63 citations

  5. Chinese Academy of Medical Sciences & Peking Union Medical College

    Beijing, China

    2 h-index

    10 publications

    150 citations

  6. NIHR Bristol Biomedical Research Centre

    Bristol, United Kingdom

    2 h-index

    7 publications

    75 citations

  7. Medical Research Council

    London, United Kingdom

    2 h-index

    16 publications

    1.1K citations

  8. First Hospital of Jilin University

    Changchun, China

    2 h-index

    11 publications

    149 citations

1–8 of 118

Venues

  1. Clinical Epigenetics

    2 publications · 33 citations

    2

    h-index

  2. The Journal of Clinical Endocrinology & Metabolism

    JCEM · 2 publications · 42 citations

    2

    h-index

  3. BMC Geriatrics

    1 publications · 23 citations

    1

    h-index

  4. Frontiers in Endocrinology

    1 publications · 58 citations

    1

    h-index

  5. Epigenetics

    1 publications · 140 citations

    1

    h-index

1–5