Two-State Binding Models is a theoretical framework in protein interaction kinetics that describes the binding process between macromolecules as an equilibrium transition occurring exclusively between two distinct conformational states—unbound and bound—thereby distinguishing it from multistate or cooperative binding mechanisms.
48
Publications
2.6K
Citations
187
Authors
94
Institutions
Publications per year
2017–2026
6
Parents
Publications
48
The two-state model of receptor activation
Paul Leff · Trends in Pharmacological Sciences · 1995 · 505 citations
A tertiary two-state allosteric model for hemoglobin
Eric R. Henry, Stefano Bettati, James Hofrichter et al. · Biophysical Chemistry · 2002 · 153 citations
1–5 of 48
Authors
187
- TB
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- GF
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- JL
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- PL
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1–5 of 187
Institutions
94
University of Pennsylvania
Philadelphia, United States
3 h-index
7 publications
553 citations
National Institutes of Health
Bethesda, United States
3 h-index
6 publications
765 citations
McGill University
Montreal, Canada
3 h-index
4 publications
307 citations
Rice University
Houston, United States
2 h-index
5 publications
156 citations
Centre National de la Recherche Scientifique
Paris, France
2 h-index
2 publications
21 citations
Délégation Paris 7
Bagnolet, France
1 h-index
1 publications
10 citations
Heinrich Heine University Düsseldorf
Düsseldorf, Germany
1 h-index
1 publications
10 citations
Johnson Foundation
Racine, United States
1 h-index
1 publications
83 citations
1–8 of 94
Venues
- Journal of Molecular Biology
JMB · 4 publications · 183 citations
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- Proceedings of the National Academy of Sciences
PNAS · 4 publications · 128 citations
4
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- Journal of the American Chemical Society
JACS · 3 publications · 250 citations
3
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- Journal of Pharmacology and Experimental Therapeutics
2 publications · 45 citations
2
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- Physical Review Letters
PRL · 2 publications · 48 citations
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1–5