Concepedia

Trough Level Targeting

Trough Level Targeting is a pharmacokinetic strategy within mTOR inhibitor therapy that involves adjusting drug dosages to maintain plasma concentrations at a predetermined minimum level immediately before the next administration, thereby optimizing therapeutic efficacy while minimizing toxicity.

16

Publications

1.2K

Citations

111

Authors

48

Institutions

Publications per year

2017–2026

6

Variants

Trough-level-guided Dosing

Parents

Publications

16

High-Dose Vancomycin Therapy for Methicillin-Resistant Staphylococcus aureus Infections

Levita Hidayat, Donald Hsu, Ryan Quist et al. · Archives of Internal Medicine · 2006 · 849 citations

, , +17

First Experience with de novo Calcineurin-Inhibitor-Free Immunosuppression Following Cardiac Transplantation

Bruno Meiser, Bruno Reichart, I Adamidis et al. · American Journal of Transplantation · 2005 · 57 citations · Full text

, , +16

Real‐life experience in switching to new extended half‐life products at European haemophilia centres

Flora Peyvandi, Isabella Garagiola, Marco Boscarino et al. · Haemophilia · 2019 · 48 citations

, , +10

Population pharmacokinetics of recombinant factor IX: implications for dose tailoring

Sven Björkman · Haemophilia · 2013 · 47 citations

, , +14

1159 Results on the Optimisation Phase of the Prospective Controlled Trough Level Adapted Infliximab Treatment (TAXIT) Trial

Niels Vande Casteele, Griet Compernolle, Vera Ballet et al. · Gastroenterology · 2012 · 43 citations · Full text

, , +7

1–5 of 16

Authors

111

  1. OK
    Osamu Konno

    Tokyo Medical University Hachioji Medical Center, Japan

    2 publications · 35 citations

    2

    h-index

  2. TH
    Toshihiko Hirano

    Tokyo University of Pharmacy and Life Sciences, Japan

    2 publications · 35 citations

    2

    h-index

  3. HI
    Hitoshi Iwamoto

    Tokyo Medical University Hachioji Medical Center, Japan

    2 publications · 35 citations

    2

    h-index

  4. NM
    Naoto Matsuno

    Tokyo Medical University Hachioji Medical Center, Japan

    2 publications · 35 citations

    2

    h-index

  5. HT
    Hirohito Takeuchi

    Tokyo Medical University, Japan

    2 publications · 35 citations

    2

    h-index

1–5 of 111

Institutions

48

  1. Rutgers, The State University of New Jersey

    New Brunswick, United States

    2 h-index

    2 publications

    26 citations

  2. Tokyo University of Pharmacy and Life Sciences

    Hachiōji, Japan

    2 h-index

    5 publications

    82 citations

  3. Tokyo Medical University Hachioji Medical Center

    Tokyo, Japan

    2 h-index

    20 publications

    383 citations

  4. Medical University of Lublin

    Lublin, Poland

    2 h-index

    2 publications

    26 citations

  5. Sheba Medical Center

    Ramat Gan, Israel

    1 h-index

    9 publications

    126 citations

  6. Tel Aviv University

    Tel Aviv, Israel

    1 h-index

    9 publications

    126 citations

  7. Vancouver General Hospital

    Vancouver, Canada

    1 h-index

    2 publications

    44 citations

  8. UCLouvain

    Louvain-la-Neuve, Belgium

    1 h-index

    1 publications

    48 citations

1–8 of 48

Venues

  1. Haemophilia

    3 publications · 113 citations

    3

    h-index

  2. Transplantation Proceedings

    2 publications · 35 citations

    2

    h-index

  3. American Journal of Transplantation

    1 publications · 57 citations

    1

    h-index

  4. Digestive and Liver Disease

    1 publications · 14 citations

    1

    h-index

  5. Hämostaseologie

    1 publications · 15 citations

    1

    h-index

1–5