Concepedia

Transition-state Engineering

Transition-State Engineering is a computational and biochemical strategy that belongs to the class of protein design methodologies, specifically distinguished by its focus on modifying enzyme active sites to stabilize stereoselective transition states through rational or algorithm-guided mutagenesis.

10

Publications

301

Citations

58

Authors

17

Institutions

Publications per year

2017–2026

5

Parents

Publications

10

Controllable transition engineering from homogeneous NiSe2 nanowrinkles to heterogeneous Ni3Se4/NiSe2 rod-like nanoarrays for promoted urea-rich water oxidation at large current densities

Xiujuan Xu, Jinyang Li, Canhui Zhang et al. · Applied Catalysis B: Environmental · 2022 · 81 citations

, , +11

Computationally Designed and Experimentally Confirmed Diastereoselective Rhodium-Catalyzed Pauson−Khand Reaction at Room Temperature

Mu‐Hyun Baik, Shivnath Mazumder, Paolo F. Ricci et al. · Journal of the American Chemical Society · 2011 · 54 citations

, , +10

Trapping a transition state in a computationally designed protein bottle

Aaron D. Pearson, Jeremy H. Mills, Yifan Song et al. · Science · 2015 · 46 citations · Full text

, , +13

Transition State-Based Sialyltransferase Inhibitors: Mimicking Oxocarbenium Ion by Simple Amide

Jian Guo, Wenming Li, Weiwei Xue et al. · Journal of Medicinal Chemistry · 2017 · 27 citations · Full text

, , +17

Reshaping Phosphatase Substrate Preference for Controlled Biosynthesis Using a “Design–Build–Test–Learn” Framework

Jiangong Lu, Xueqin Lv, Wenwen Yu et al. · Advanced Science · 2024 · 24 citations · Full text

, , +17

1–5 of 10

Authors

58

  1. WX
    Weiwei Xue

    Chongqing University, China

    1 publications · 27 citations

    1

    h-index

  2. HS
    Huaichang Sun

    Yangzhou University, China

    1 publications · 12 citations

    1

    h-index

  3. JH
    Jeremy H. Mills

    Arizona State University, United States

    1 publications · 46 citations

    1

    h-index

  4. MH
    Minghua Huang

    Ocean University of China, China

    1 publications · 81 citations

    1

    h-index

  5. WL
    Wenming Li

    Peking University, China

    1 publications · 27 citations

    1

    h-index

1–5 of 58

Institutions

17

  1. Chongqing University

    Chongqing, China

    1 h-index

    1 publications

    27 citations

  2. University of Calgary

    Calgary, Canada

    1 h-index

    7 publications

    133 citations

  3. Jiangnan University

    Wuxi, China

    1 h-index

    10 publications

    240 citations

  4. University of Memphis

    Memphis, United States

    1 h-index

    3 publications

    36 citations

  5. Peking University

    Beijing, China

    1 h-index

    3 publications

    81 citations

  6. Yangzhou University

    Yangzhou, China

    1 h-index

    5 publications

    60 citations

  7. Memphis Health Center

    Memphis, United States

    1 h-index

    3 publications

    36 citations

  8. Hong Kong Polytechnic University

    Hong Kong, Hong Kong

    1 h-index

    4 publications

    60 citations

1–8 of 17

Venues

  1. Protein Expression and Purification

    1 publications · 12 citations

    1

    h-index

  2. 1

    h-index

  3. Advanced Science

    1 publications · 24 citations

    1

    h-index

  4. Journal of Medicinal Chemistry

    1 publications · 27 citations

    1

    h-index

  5. Science

    1 publications · 46 citations

    1

    h-index

1–5