Concepedia

Transition State Design

Transition State Design is a computational enzyme design methodology that belongs to the class of rational design strategies, distinguished by its focus on stabilizing the transition state of a chemical reaction through precise active-site engineering to enhance catalytic efficiency and specificity.

161

Publications

9.9K

Citations

637

Authors

205

Institutions

Publications per year

2017–2026

39

Parents

Publications

161

Contact order, transition state placement and the refolding rates of single domain proteins 1 1Edited by P. E. Wright

Kevin W. Plaxco, Kim T. Simons, David Baker · Journal of Molecular Biology · 1998 · 1.5K citations

, , +17

Mapping the transition state and pathway of protein folding by protein engineering

Andreas Matouschek, James T. Kellis, Luis Serrano et al. · Nature · 1989 · 707 citations

, , +16

Conjugate peak refinement: an algorithm for finding reaction paths and accurate transition states in systems with many degrees of freedom

Stefan Fischer, Martin Karplus · Chemical Physics Letters · 1992 · 487 citations

, , +11

Design of Acid−Base Catalysis for the Asymmetric Direct Aldol Reaction

Susumu Saito, Hisashi Yamamoto · Accounts of Chemical Research · 2004 · 390 citations

, , +17

Hydrogen-Bonding Directed Reversal of Enantioselectivity

Wei Zeng, Yong‐Gui Zhou, Yu‐Xue Li · Journal of the American Chemical Society · 2007 · 235 citations

, , +11

1–5 of 161

Authors

637

  1. VL
    Vern L. Schramm

    Albert Einstein College of Medicine, United States

    8 publications · 462 citations

    8

    h-index

  2. PC
    Peter C. Tyler

    Albert Einstein College of Medicine, United States

    5 publications · 325 citations

    5

    h-index

  3. RH
    Richard H. Furneaux

    Albert Einstein College of Medicine, United States

    4 publications · 281 citations

    4

    h-index

  4. GB
    Gary B. Evans

    Albert Einstein College of Medicine, United States

    3 publications · 232 citations

    3

    h-index

  5. AS
    Acharan S. Narula

    Australian National University, Australia

    3 publications · 133 citations

    3

    h-index

1–5 of 637

Institutions

205

  1. Albert Einstein College of Medicine

    Bronx, United States

    10 h-index

    41 publications

    2.7K citations

  2. Yeshiva University

    New York, United States

    6 h-index

    19 publications

    1.5K citations

  3. Shanghai Institute of Organic Chemistry

    Shanghai, China

    5 h-index

    11 publications

    1.1K citations

  4. Nagoya University

    Nagoya, Japan

    4 h-index

    12 publications

    1.3K citations

  5. Chinese Academy of Sciences

    Beijing, China

    4 h-index

    14 publications

    524 citations

  6. Australian National University

    Canberra, Australia

    3 h-index

    4 publications

    165 citations

  7. University of Cambridge

    Cambridge, United Kingdom

    3 h-index

    8 publications

    2.6K citations

  8. Kyoto University

    Kyoto, Japan

    3 h-index

    5 publications

    239 citations

1–8 of 205

Venues

  1. The Journal of Organic Chemistry

    JOC · 20 publications · 592 citations

    15

    h-index

  2. Journal of the American Chemical Society

    JACS · 15 publications · 1K citations

    14

    h-index

  3. Organic Letters

    OL · 9 publications · 291 citations

    9

    h-index

  4. Tetrahedron Letters

    7 publications · 168 citations

    7

    h-index

  5. Biochemistry

    6 publications · 310 citations

    6

    h-index

1–5