Concepedia

Transcription-replication Conflicts

Transcription-Replication Conflicts is a biological phenomenon in which the transcription machinery, particularly RNA Polymerase II, and the DNA replication machinery interfere with each other’s progression on the same genomic template, leading to genomic instability due to their opposing directional movement or spatiotemporal overlap.

91

Publications

6.4K

Citations

652

Authors

227

Institutions

Publications per year

2017–2026

70

Variants

Trcs

Parents

Publications

91

Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses

Stephan Hamperl, M Bocek, Joshua C. Saldivar et al. · Cell · 2017 · 677 citations · Full text

, , +12

Replication-Transcription Conflicts Generate R-Loops that Orchestrate Bacterial Stress Survival and Pathogenesis

Kevin S. Lang, Ashley N. Hall, Christopher N. Merrikh et al. · Cell · 2017 · 264 citations · Full text

, , +14

Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance

Tanita Wein, Nils F. Hülter, Itzhak Mizrahi et al. · Nature Communications · 2019 · 237 citations · Full text

, , +17

Co-Orientation of Replication and Transcription Preserves Genome Integrity

Anjana Srivatsan, Ashley K. Tehranchi, David M. MacAlpine et al. · PLoS Genetics · 2010 · 200 citations · Full text

, , +14

The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription–replication conflicts

Emilia Herrera‐Moyano, Xénia Mergui, María García‐Rubio et al. · Genes & Development · 2014 · 194 citations · Full text

, , +17

1–5 of 91

Authors

652

  1. HM
    Houra Merrikh

    University of Washington, United States

    8 publications · 892 citations

    8

    h-index

  2. AA
    Andrés Aguilera

    Universidad de Sevilla, Spain

    8 publications · 609 citations

    8

    h-index

  3. CR
    Christian Rudolph

    University of Nottingham, United Kingdom

    4 publications · 171 citations

    4

    h-index

  4. JU
    Juachi U. Dimude

    Brunel University of London, United Kingdom

    4 publications · 171 citations

    4

    h-index

  5. PC
    Peter C. Stirling

    University of British Columbia, Canada

    4 publications · 257 citations

    4

    h-index

1–5 of 652

Institutions

227

  1. Centro Andaluz de Biología Molecular y Medicina Regenerativa

    Seville, Spain

    8 h-index

    31 publications

    2.5K citations

  2. Universidad de Sevilla

    Seville, Spain

    8 h-index

    32 publications

    2.6K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    33 publications

    2.3K citations

  4. University of Washington

    Seattle, United States

    6 h-index

    25 publications

    3.6K citations

  5. University of Nottingham

    Nottingham, United Kingdom

    5 h-index

    10 publications

    1.4K citations

  6. University of Birmingham

    Birmingham, United Kingdom

    5 h-index

    27 publications

    1.2K citations

  7. University of British Columbia

    Vancouver, Canada

    5 h-index

    8 publications

    416 citations

  8. University of Copenhagen

    Copenhagen, Denmark

    4 h-index

    12 publications

    540 citations

1–8 of 227

Venues

  1. Nucleic Acids Research

    15 publications · 515 citations

    14

    h-index

  2. Nature Communications

    14 publications · 1K citations

    13

    h-index

  3. Cell Reports

    9 publications · 458 citations

    9

    h-index

  4. Molecular Cell

    6 publications · 419 citations

    6

    h-index

  5. Nature

    6 publications · 772 citations

    6

    h-index

1–5