Concepedia

Transcription Factor Engineering

Transcription Factor Engineering is a strain improvement methodology that involves the targeted modification of transcription factors to regulate the expression of genes involved in secondary metabolite biosynthesis, thereby enhancing or altering metabolic output in microbial or plant systems.

87

Publications

6.1K

Citations

553

Authors

176

Institutions

Publications per year

2017–2026

34

Parents

Publications

87

Engineering Yeast Transcription Machinery for Improved Ethanol Tolerance and Production

Hal S. Alper, Joel F. Moxley, Elke Nevoigt et al. · Science · 2006 · 847 citations

, , +15

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening

Chao Wang, Michael E. Ward, Robert Y. Chen et al. · Stem Cell Reports · 2017 · 465 citations · Full text

, , +17

Global transcription machinery engineering: A new approach for improving cellular phenotype

Hal S. Alper, George Stephanopoulos · Metabolic Engineering · 2007 · 455 citations

, , +15

Engineering an allosteric transcription factor to respond to new ligands

Noah D. Taylor, Alexander S. Garruss, Rocco Moretti et al. · Nature Methods · 2015 · 350 citations · Full text

, , +14

Positive and negative regulation of endogenous genes by designed transcription factors

Roger R. Beerli, Birgit Dreier, Carlos F. Barbas · Proceedings of the National Academy of Sciences · 2000 · 348 citations

, , +17

1–5 of 87

Authors

553

  1. HS
    Hal S. Alper

    The University of Texas at Austin, United States

    5 publications · 1.4K citations

    5

    h-index

  2. CC
    Casey C. Case

    Sangamo BioSciences (United States), United States

    4 publications · 171 citations

    4

    h-index

  3. EJ
    Edward J. Rebar

    Sangamo BioSciences (United States), United States

    4 publications · 206 citations

    4

    h-index

  4. PD
    Philip D. Gregory

    Sangamo BioSciences (United States), United States

    3 publications · 97 citations

    3

    h-index

  5. EG
    Erich Grotewold

    The Ohio State University, United States

    3 publications · 390 citations

    3

    h-index

1–5 of 553

Institutions

176

  1. Chinese Academy of Sciences

    Beijing, China

    6 h-index

    29 publications

    753 citations

  2. Sangamo BioSciences (United States)

    Richmond, United States

    5 h-index

    44 publications

    2.1K citations

  3. University of Chinese Academy of Sciences

    Beijing, China

    4 h-index

    12 publications

    292 citations

  4. Tianjin Institute of Industrial Biotechnology

    Tianjin, China

    3 h-index

    18 publications

    519 citations

  5. The University of Texas at Austin

    Austin, United States

    3 h-index

    9 publications

    276 citations

  6. Tianjin University

    Tianjin, China

    3 h-index

    17 publications

    557 citations

  7. Chalmers University of Technology

    Gothenburg, Sweden

    2 h-index

    4 publications

    202 citations

  8. Hubei University of Technology

    Wuhan, China

    2 h-index

    8 publications

    211 citations

1–8 of 176

Venues

  1. ACS Synthetic Biology

    7 publications · 236 citations

    7

    h-index

  2. Biotechnology for Biofuels

    5 publications · 293 citations

    5

    h-index

  3. Biotechnology and Bioengineering

    4 publications · 163 citations

    4

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 509 citations

    4

    h-index

  5. Methods in molecular biology

    Book series · 4 publications · 77 citations

    4

    h-index

1–5