Tissue Stiffening

Tissue Stiffening is a biomechanical phenomenon characterized by an increase in the elastic modulus of extracellular matrix networks within a tissue, resulting from alterations in matrix composition, crosslinking density, or cellular contractility that collectively enhance tissue rigidity beyond physiological norms.

704

Publications

55.7K

Citations

Authors

1.1K

Institutions

Publications per year

2017–2026

269

Parents

Cellular MechanicsMatrix Stiffness

Publications

704

Aortic Stiffness, Blood Pressure Progression, and Incident Hypertension

Bernhard M. Kaess, Jian Rong, Martin G. Larson et al. · JAMA · 2012 · 1.1K citations · Full text

Medicine, Cardiology, Physiology +15

Role of Subchondral Bone in the Initiation and Progression of Cartilage Damage

Eric L. Radin, Robert M. Rose · Clinical Orthopaedics and Related Research · 1986 · 1.1K citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +17

Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility – Reykjavik Study

Gary F. Mitchell, Mark A. van Buchem, Sigurður Sigurðsson et al. · Brain · 2011 · 888 citations · Full text

Medicine, Neurology, Neuroscience +17

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

Fei Liu, Justin D. Mih, Barry S. Shea et al. · The Journal of Cell Biology · 2010 · 817 citations · Full text

Life Sciences, Cell Biology, Pathobiology +17

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

Jörg Schrader, Timothy T. Gordon‐Walker, Rebecca L. Aucott et al. · Hepatology · 2010 · 735 citations · Full text

Medicine, Bioengineering, Oncology +17

1–5 of 704

Authors

PA
Paul A. Janmey
University of Pennsylvania, United States
12 publications · 1.7K citations
12
h-index
DJ
Daniel J. Tschumperlin
Mayo Clinic, United States
12 publications · 1.8K citations
10
h-index
RK
Richard K. Assoian
University of Pennsylvania, United States
8 publications · 1.1K citations
8
h-index
CA
Cynthia A. Reinhart‐King
Cornell University, United States
7 publications · 1K citations
7
h-index
YB
Yongho Bae
University of Pennsylvania, United States
6 publications · 647 citations
6
h-index

1–5 of 4K

Institutions

1.1K

1–8 of 1.1K

Venues

PLoS ONE
27 publications · 2.2K citations
22
h-index
Scientific Reports
21 publications · 1.2K citations
19
h-index
American Journal of Physiology-Heart and Circulatory Physiology
19 publications · 893 citations
18
h-index
Hypertension
17 publications · 1.3K citations
16
h-index
Biophysical Journal
13 publications · 1.1K citations
12
h-index

1–5