Concepedia

Tip Cell Dynamics

Tip Cell Dynamics is a biological process that characterizes the leading-edge behavior of specialized endothelial cells during angiogenesis, distinguished by their role in sensing guidance cues, directing vascular sprout formation, and coordinating with follower cells through dynamic cellular extensions and signaling interactions in the tumor microenvironment.

118

Publications

11.4K

Citations

601

Authors

257

Institutions

Publications per year

2017–2026

29

Parents

Publications

118

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

Alessandro Fantin, Joaquim Miguel Vieira, Gaia Gestri et al. · Blood · 2010 · 1.2K citations · Full text

, , +16

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

Lars Jakobsson, Cláudio A. Franco, Katie Bentley et al. · Nature Cell Biology · 2010 · 976 citations

, , +16

VEGF and Notch in Tip and Stalk Cell Selection

Rosa Blanco, Holger Gerhardt · Cold Spring Harbor Perspectives in Medicine · 2012 · 619 citations · Full text

, , +17

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

Duc-Huy T. Nguyen, Sarah C. Stapleton, Michael T. Yang et al. · Proceedings of the National Academy of Sciences · 2013 · 500 citations · Full text

, , +16

TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype

Richard C.A. Sainson, Douglas A. Johnston, Henry C. Chu et al. · Blood · 2008 · 323 citations · Full text

, , +16

1–5 of 118

Authors

601

  1. HG
    Holger Gerhardt

    Cancer Research UK, United Kingdom

    9 publications · 2.8K citations

    9

    h-index

  2. KB
    Katie Bentley

    Beth Israel Deaconess Medical Center, United States

    7 publications · 1.7K citations

    7

    h-index

  3. IM
    Irene M. Aspalter

    University College London, United Kingdom

    5 publications · 1.3K citations

    5

    h-index

  4. IK
    Ingeborg Klaassen

    University of Amsterdam, Netherlands

    4 publications · 343 citations

    4

    h-index

  5. HM
    Helen M. Byrne

    University of Oxford, United Kingdom

    4 publications · 135 citations

    4

    h-index

1–5 of 601

Institutions

257

  1. KU Leuven

    Leuven, Belgium

    7 h-index

    39 publications

    4.7K citations

  2. Cancer Research UK

    London, United Kingdom

    6 h-index

    26 publications

    11.1K citations

  3. Harvard University

    Cambridge, United States

    6 h-index

    20 publications

    996 citations

  4. The Honourable Society of Lincoln's Inn

    London, United Kingdom

    5 h-index

    15 publications

    9.2K citations

  5. University College London

    London, United Kingdom

    4 h-index

    10 publications

    3.3K citations

  6. Leiden University

    Leiden, The Netherlands

    4 h-index

    6 publications

    377 citations

  7. VIB-KU Leuven Center for Cancer Biology

    Leuven, Belgium

    4 h-index

    33 publications

    3.4K citations

  8. Max Delbrück Center

    Berlin, Germany

    4 h-index

    11 publications

    1.8K citations

1–8 of 257

Venues

  1. Development

    9 publications · 781 citations

    9

    h-index

  2. Nature Communications

    5 publications · 617 citations

    5

    h-index

  3. Angiogenesis

    5 publications · 385 citations

    5

    h-index

  4. Scientific Reports

    5 publications · 345 citations

    5

    h-index

  5. Developmental Biology

    4 publications · 88 citations

    4

    h-index

1–5