Concepedia

Time-dependent Protein Binding

Time-Dependent Protein Binding is a pharmacokinetic phenomenon characterized by a time-varying association between a drug and plasma proteins, distinguishing it from static protein binding by accounting for dynamic changes in binding affinity or capacity over time.

37

Publications

1.6K

Citations

158

Authors

66

Institutions

Publications per year

2017–2026

6

Parents

Publications

37

Understanding the Lipid and Protein Corona Formation on Different Sized Polymeric Nanoparticles

Tânia Lima, Katja Bernfur, Manuel Vilanova et al. · Scientific Reports · 2020 · 234 citations · Full text

, , +17

Interaction of antithrombin III with bovine aortic segments. Role of heparin in binding and enhanced anticoagulant activity.

D Stern, Peter P. Nawroth, James A. Marcum et al. · Journal of Clinical Investigation · 1985 · 109 citations · Full text

, , +16

Understanding the Hysteresis Loop Conundrum in Pharmacokinetic / Pharmacodynamic Relationships

Christopher Louizos, Jaime A. Yáñez, M. Laird Forrest et al. · Journal of Pharmacy & Pharmaceutical Sciences · 2014 · 96 citations · Full text

, , +17

In vivo diffusion of immunoglobulin G in muscle: effects of binding, solute exclusion, and lymphatic removal

Michael F. Flessner, Joanne Lofthouse, El Rasheid Zakaria · American Journal of Physiology-Heart and Circulatory Physiology · 1997 · 82 citations

, , +15

Understanding the hysteresis loop conundrum in pharmacokinetic/pharmacodynamic relationships.

Christopher Louizos, Jaime A. Yáñez, M. Laird Forrest et al. · PubMed · 2014 · 78 citations · Full text

, , +17

1–5 of 37

Authors

158

  1. GL
    Gerhard Levy

    University at Buffalo, State University of New York, United States

    2 publications · 94 citations

    2

    h-index

  2. JA
    Jaime A. Yáñez

    Universidad de Lima, Peru

    2 publications · 174 citations

    2

    h-index

  3. CL
    Christopher Louizos

    University of Manitoba, Canada

    2 publications · 174 citations

    2

    h-index

  4. ML
    M. Laird Forrest

    University of Kansas, United States

    2 publications · 174 citations

    2

    h-index

  5. KT
    Klaus T. Preissner

    Justus-Liebig-Universität Gießen, Germany

    1 publications · 34 citations

    1

    h-index

1–5 of 158

Institutions

66

  1. University of Washington

    Seattle, United States

    3 h-index

    13 publications

    1K citations

  2. University of California San Diego

    San Diego, United States

    2 h-index

    4 publications

    122 citations

  3. National University of Singapore

    Singapore, Singapore

    2 h-index

    4 publications

    142 citations

  4. University of Manitoba

    Winnipeg, Canada

    2 h-index

    3 publications

    270 citations

  5. Institute of Human Genetics

    Poznań, Poland

    1 h-index

    1 publications

    55 citations

  6. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    1 h-index

    6 publications

    294 citations

  7. Western University

    London, Canada

    1 h-index

    2 publications

    38 citations

  8. University of Kansas

    Lawrence, United States

    1 h-index

    1 publications

    96 citations

1–8 of 66

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 170 citations

    4

    h-index

  2. Journal of Pharmaceutical Sciences

    2 publications · 25 citations

    2

    h-index

  3. Scientific Reports

    2 publications · 246 citations

    2

    h-index

  4. Antimicrobial Agents and Chemotherapy

    AAC · 2 publications · 42 citations

    2

    h-index

  5. 1

    h-index

1–5