Concepedia

Tight-binding Inhibition

Tight-Binding Inhibition is a type of enzyme inhibition characterized by the formation of a stable enzyme-inhibitor complex with dissociation constants approaching the enzyme's active site concentration, resulting in potent and often near-stoichiometric inhibition.

465

Publications

35.2K

Citations

2.1K

Authors

602

Institutions

Publications per year

2017–2026

39

Parents

Publications

465

Humanization of an anti-p185HER2 antibody for human cancer therapy.

Paul Carter, Leonard G. Presta, C Gorman et al. · Proceedings of the National Academy of Sciences · 1992 · 1.9K citations

, , +16

Enzymes: a practical introduction to structure, mechanism, and data analysis

Choice Reviews Online · 2001 · 1.1K citations

, , +17

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.

Satomi Matsuoka, Michael C. Edwards, Chang-Ming Bai et al. · Genes & Development · 1995 · 954 citations · Full text

, , +17

1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo

Edward P. Garvey, Jeffrey A. Oplinger, Eric S. Furfine et al. · Journal of Biological Chemistry · 1997 · 851 citations · Full text

, , +10

Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

John F. Morrison · Biochimica et Biophysica Acta (BBA) - Enzymology · 1969 · 814 citations

, , +16

1–5 of 465

Authors

2.1K

  1. VL
    Vern L. Schramm

    Albert Einstein College of Medicine, United States

    12 publications · 629 citations

    12

    h-index

  2. PC
    Peter C. Tyler

    Albert Einstein College of Medicine, United States

    7 publications · 335 citations

    7

    h-index

  3. RG
    Ronald G. Duggleby

    The University of Queensland, Australia

    6 publications · 266 citations

    6

    h-index

  4. GB
    Gary B. Evans

    Albert Einstein College of Medicine, United States

    6 publications · 281 citations

    6

    h-index

  5. JF
    John F. Morrison

    Australian National University, Australia

    5 publications · 2.1K citations

    5

    h-index

1–5 of 2.1K

Institutions

602

  1. Albert Einstein College of Medicine

    Bronx, United States

    13 h-index

    63 publications

    3.4K citations

  2. Harvard University

    Cambridge, United States

    12 h-index

    31 publications

    2.9K citations

  3. University of Wisconsin–Madison

    Madison, United States

    10 h-index

    21 publications

    1K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    41 publications

    3.7K citations

  5. Scripps Research Institute

    San Diego, United States

    9 h-index

    23 publications

    2K citations

  6. University of Washington

    Seattle, United States

    7 h-index

    23 publications

    2.8K citations

  7. National Institutes of Health

    Bethesda, United States

    7 h-index

    29 publications

    2.7K citations

  8. University of Michigan

    Ann Arbor, United States

    7 h-index

    18 publications

    878 citations

1–8 of 602

Venues

  1. Journal of Biological Chemistry

    JBC · 61 publications · 6.1K citations

    42

    h-index

  2. Biochemistry

    64 publications · 4K citations

    34

    h-index

  3. Journal of Medicinal Chemistry

    29 publications · 1.9K citations

    24

    h-index

  4. Journal of the American Chemical Society

    JACS · 21 publications · 1.2K citations

    19

    h-index

  5. Biochemical Journal

    BJ · 22 publications · 1.6K citations

    18

    h-index

1–5