Tight Junction Biogenesis is a cellular developmental process that refers to the de novo formation and assembly of tight junction components at the apical region of polarized epithelial and endothelial cells, distinguishing it from other junctional assembly mechanisms by its specific spatiotemporal regulation of transmembrane and cytoplasmic scaffolding proteins to establish paracellular barrier function.
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Alexander E.E. Mertens, Tomasz P. Rygiel, Cristina Olivo et al. · The Journal of Cell Biology · 2005 · 233 citations · Full text
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